Selectins as Mediators of Lung Metastasis
نویسندگان
چکیده
منابع مشابه
Selectins Mediate Small Cell Lung Cancer Systemic Metastasis
Metastasis formation is the major reason for the extremely poor prognosis in small cell lung cancer (SCLC) patients. The molecular interaction partners regulating metastasis formation in SCLC are largely unidentified, however, from other tumor entities it is known that tumor cells use the adhesion molecules of the leukocyte adhesion cascade to attach to the endothelium at the site of the future...
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Cancer metastasis is facilitated by cell-cell interactions between cancer cells and endothelial cells in distant tissues. In addition, cancer cell interactions with platelets and leukocytes contribute to cancer cell adhesion, extravasation, and the establishment of metastatic lesions. Selectins are carbohydrate-binding molecules that bind to sialylated, fucosylated glycan structures, and are fo...
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ژورنال
عنوان ژورنال: Cancer Microenvironment
سال: 2010
ISSN: 1875-2292,1875-2284
DOI: 10.1007/s12307-010-0043-6